Precocious development of uridine diphosphate glucuronyltransferase activity in chick-embryo liver after administration of 11beta-hydroxy steroids with and without thyroxine.
نویسندگان
چکیده
Brady, R. O., Kanfer, J. N. & Shapiro, D. (1965) Biochem. Biophys. Res. Commun. 18,221-225 Brady, R. O., Pentchev, P. G., Gal, A. E., Hibbert, S. R. & Dekaban, A. S. (1974) N. Engl. J. Med. 291,989-993 Gregoriadis, G. (1974) in Enzyme Replacement Therapy of Lysosomal Storage Diseases (Tager, J. M., Hooghwinke1.G. J. M. &Daems, W. Th.,eds.),pp. 131-148,North-Holland Publishing Co., Amsterdam and Oxford Gregoriadis, G. & Buckland, R. A. (1973) Nature (London) 244, 17C172 Gregoriadis, G., Swain, C. P., Wills, E. J. & Tavill, A. S. (1974) Lancet i , 1313-1316 Ho, M. W. (1973) Biochem. J. 136,721-729
منابع مشابه
Development of uridine diphosphate-glucuronyltransferase activity in cultures of chick-embryo liver.
1. The liver of the domestric fowl (Gallus gallus) remains capable of conjugating o-aminophenol with glucuronic acid after 8 days' culture. The pathway of o-aminophenyl glucuronide formation in cultured liver, as in fresh tissue, includes the enzyme UDP-glucuronyltransferase. 2. UDP-glucuronyltransferase activity in chick-embryo liver increases on culture from very low to adult values within 6-...
متن کاملThe biosynthesis and induction of microsomal UDP-glucuronyltransferase in avian liver.
Introduction The molecular mechanisms involved in the regulation of hepatic microsomal UDP-glucuronyltransferases are currently the subject of rigorous investigations by a number of laboratories. Overwhelming evidence indicates that UDPglucuronyltransferase is a heterogeneous family of enzymes (see Burchell, 1981); thus these investigations in mammalian tissues are complicated by the specificit...
متن کاملDevelopment of Phenobarbital-sensitive Control Mechanisms for Uridine Diphosphate Glucuronyltransferase Activity in Chick Embryo Liver
Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult...
متن کاملIdentification of increased amounts of UDP-glucuronyltransferase protein in phenobarbital-treated chick-embryo liver cells.
UDP-glucuronyltransferase activity of neonatal-chick liver or phenobarbital-treated chick-embryo liver catalysed the glucuronidation of 1-naphthol, 4-nitrophenol and 2-aminophenol. Only low transferase activity towards testosterone was detected, and activity towards bilirubin was not detectable. Liver microsomal transferase activity towards the three phenols was increased approx. 20-50-fold by ...
متن کاملProliferation of endoplasmic reticulum with its enzyme, UDP- glucuronyltransferase, in chick embryo liver during culture. Effects of phenobarbital
UDP-Glucuronyltransferase (GT) activity increases in chick embryo liver during culture from zero to a steady-state level at or above adult values. The GT activity (o-aminophenol as acceptor) is located entirely in the membranes of the endoplasmic reticulum (ER) and the question arises whether ER increases along with GT. Earlier work showed that the synthesis and degradation rates of GT can be v...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1976